Dapoxetine, marketed as Priligy, among others, is a medication used for the treatment of premature ejaculation (PE) in men 18–64 years old. [3] [4] [5] Dapoxetine works by inhibiting the serotonin transporter, increasing serotonin’s action at the postsynaptic cleft, and as a consequence promoting ejaculatory delay. [6].If you have any questions about this medicine ask your pharmacist. Table 4 Summary of core evidence for dapoxetine in the treatment of lifelong or acquired premature ejaculation Outcome measure. Dapoxetine 30 mg and 60 mg has been evaluated in five industry-sponsored randomized, double-blind, placebo-controlled studies in men aged at least 18 years. Your doctor will only prescribe the higher dose for you if the 30 mg dose is insufficient, and providing you have not experienced any side-effects such as feeling faint. The disease-oriented efficacy of dapoxetine has been shown in the studies examined here to be supported by positive effects in all patient-reported outcomes, which together indicate a significant improvement in wellbeing and quality of life. This search was then manually cross referenced for all papers. In the same study, patients achieving the composite patient-reported outcome reported longer IELTs than those reported by the overall treatment groups, ie, 5.Common or very common. Anxiety; asthenia; concentration impaired; constipation; diarrhoea; dizziness; drowsiness; dry mouth; gastrointestinal discomfort; gastrointestinal disorders; headache; hypotension; mood altered; nausea; paraesthesia; sexual dysfunction; sinus congestion; sleep disorders; sweat changes; syncope; tinnitus; tremor. Dapoxetine, marketed as Priligy, among others, is a medication used for the treatment of premature ejaculation (PE) in men 18–64 years old. [3] [4] [5] Dapoxetine works by inhibiting the serotonin transporter, increasing serotonin’s action at the postsynaptic cleft, and as a consequence promoting ejaculatory delay. [6]. Scope, aims, and objectives. Dapoxetine (Priligy TM, Johnson and Johnson, Raritan, NJ) is the first and only product licensed for the treatment of premature ejaculation (PE) in men aged 18–64 years. At present, dapoxetine is licensed in ten countries, including several countries in Europe, and Mexico, South Korea, and New Zealand. 1, 2 .In the paper by McMahon et al, the proportions achieving the composite patient-reported outcome were Keywords: dapoxetine, premature ejaculation, treatment, selective serotonin re-uptake inhibitors Introduction Over the past 20—30 years, the premature ejaculation PE treatment paradigm, previously limited to behavioural psychotherapy, has expanded to include drug treatment [ Jannini et al. The most common treatment-related adverse effects included nausea It is rapidly absorbed and eliminated, resulting in minimal accumulation, and has dose-proportional pharmacokinetics which are unaffected by multiple dosing. The two integrated analyses reporting this outcome found significantly better CGI scores compared with placebo at study endpoint. Ques : Is Dapoxetine safe?

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