Dapoxetine, marketed as Priligy, among others, is a medication used for the treatment of premature ejaculation (PE) in men 18–64 years old. Dapoxetine works by inhibiting the serotonin transporter, increasing serotonin’s action at the postsynaptic cleft, and as a consequence promoting ejaculatory delay. As a See more.A chemical in grapefruit juice can increase the amount of dapoxetine in your bloodstream and this increases the risk of side-effects. Animal and human sexual psychopharmacological studies have demonstrated that serotonin 5-hydroxy-tryptamine, 5-HT and 5-HT receptors are involved in ejaculation and confirm a role for selective serotonin reuptake inhibitors SSRIs in the treatment of PE [ Olivier et al. Information given here is based on the salt content of the medicine. On the basis of these results, the mg dose was selected to be further evaluated in the phase 3 trials. In comparison, the placebo group went from a baseline of 0. Here, we describe the findings from these investigations that characterize the cardiovascular safety profile of dapoxetine. Both doses of dapoxetine also demonstrated improvement compared with placebo for the secondary end points. · The starting dose for all patients is 30 mg. Take as needed approximately 1 to 3 hours prior to sexual activity. Treatment with dapoxetine should not be initiated with . The effects of PDE-5 inhibitors on the pharmacokinetics of dapoxetine were studied in a randomized, open-label, 3-period crossover study in healthy male subjects . The most common AE was nausea and occurred in %, % and % of subjects with placebo, dapoxetine 60 mg and dapoxetine mg respectively. Overall, dapoxetine .Dapoxetine for the treatment of men with premature ejaculation PE :dose-finding analysis [abstract]. It was also shown to bind and inhibit the reuptake transporters of dopamine and norepinephrine. There were no clinically relevant mean changes in ECG or vital sign data. Ans : Dapoxetine is used to cure premature ejaculation in men between 18 and 64 years of age. Both integrated analyses found significant reductions in distress related to ejaculation at study endpoint following dapoxetine treatment. The most common adverse event was dizziness, occurring in 2.