How long does the effect of dapoxetine last? A: Dapoxetine should be taken 1–3 h before sexual activity, no more than once/24 h (Priligy Product Insert). Dapoxetine plasma .If you have ever had an allergic reaction to a medicine. For further information on contraindications, cautions and warnings please refer to the summary of product characteristics. Thirty-percent of the men who discontinued dapoxetine did so because of high cost. Dapoxetine is a selective serotonin reuptake inhibitor medicine which has been specially developed for the treatment of premature ejaculation. If you suspect that you or someone else might have taken an overdose of this medicine, go to the accident and emergency department of your local hospital.Dapoxetine is a short-acting selective serotonin-reuptake inhibitor (SSRI). The time to maximum plasma concentration is about 1 to 2 hours after intake. Plasma levels are . Dosage, administration, and formulation. Oral dapoxetine is indicated for the treatment of men. If they had stopped taking dapoxetine, they discussed the reasons why. Overall, 10% of the men continued taking dapoxetine for the entire two years. Discontinuation rates .After 24 weeks of dapoxetine therapy, the trial by Buvat et al found Only 3 of the studies included in the pooled analysis stated how frequently men were to try to attempt sexual intercourse; the other 2 included studies did not state this. They began taking 30 mg of dapoxetine one to three hours before intercourse. Patient-reported outcome-defined level of clinical benefit Three of the RCTs in Table 3 also reported a predefined composite clinical outcome as a measure of clinical benefit following dapoxetine treatment. However, there are no RCTs that compare ‘on demand’ dapoxetine with an active comparator, such as daily use of a longer-acting SSRI off-label use. Context Alternative treatments The European Association of Urology guidelines on male sexual dysfunction recommend that pharmacological treatment options include ‘on demand’ dapoxetine, daily use of a longer-acting selective serotonin reuptake inhibitor SSRI [off-label use], daily use of clomipramine off-label use , ‘on demand’ topical local anaesthetic agents off-label use and ‘on demand’ tramadol off-label use. Do not take more than one tablet in any 24 hours.